Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240613 | 0.94 | JAK2 (0.41) | JAK2TDP1SYKPDE4APDE4B | |
| SCHEMBL9435466 | 0.79 | CCNE2 (0.47) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6690200 | 0.78 | TDP1 (0.49) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6803680 | 0.78 | TDP1 (0.40) | TDP1SYKPDE4APDE4BPDE4C | |
| SCHEMBL6465128 | 0.77 | TDP1 (0.41) | TDP1SYKPDE4APDE4BPDE4C | |
| SCHEMBL6463075 | 0.77 | TDP1 (0.41) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7263078 | 0.73 | HDAC1 (0.41) | TDP1CCNE2CCNE1CDK2TSHR | |
| SCHEMBL10047121 | 0.73 | HDAC1 (0.39) | CCNE2CCNE1CDK2 | |
| SCHEMBL3130095 | 0.72 | TDP1 (0.48) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6803674 | 0.72 | HDAC1 (0.46) | TDP1SYKPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543019-A2 | MODIFIED PNA MOLECULES | Santaris Pharma A/S (DK) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004024757-A2 | MODIFIED PNA MOLECULES | SANTARIS PHARMA A/S (DK) | 2004-03-25 | — | — | WO | disclosed |