Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 17/20 | 0.73 |
| ▸ | PPARA | Q07869 | 12/20 | 0.73 |
| ▸ | PPARG | P37231 | 9/20 | 0.73 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6241282 | 0.92 | PPARD (0.61) | PPARDPPARAPPARGFFAR1MAPT | |
| SCHEMBL6234121 | 0.85 | PPARD (1.00) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL5480585 | 0.83 | PPARD (0.79) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL6237998 | 0.82 | PPARD (0.74) | PPARDPPARAPPARGFFAR1MAPT | |
| SCHEMBL6238011 | 0.82 | PPARD (0.74) | PPARDPPARAPPARGFFAR1MAPT | |
| SCHEMBL6236846 | 0.81 | PPARD (0.74) | PPARDPPARAPPARGFFAR1FFAR2 | |
| SCHEMBL6242575 | 0.80 | PPARD (0.74) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL4677201 | 0.80 | PPARD (0.59) | PPARDPPARAPPARGFFAR1MAPT | |
| SCHEMBL6237277 | 0.80 | PPARD (0.72) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL14436385 | 0.79 | PPARD (0.71) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189895-B8 | THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1189895-B1 | THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2005-06-08 | — | — | EP | disclosed |
| US-6710063-B1 | Activators of PPAR delta | SMITHKLINE BEECHAM CORPORATION | 2004-03-23 | — | — | US | disclosed |
| EP-1189895-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GLAXO GROUP LIMITED (GB) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001000603-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GLAXO GROUP LIMITED (GB) | 2001-01-04 | — | — | WO | disclosed |