Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.73 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.73 |
| ▸ | MTOR | P42345 | 5/20 | 0.73 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.73 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.73 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.73 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.73 |
| ▸ | PRKDC | P78527 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.73 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.73 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.73 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.73 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.73 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.73 |
| ▸ | PI4KA | P42356 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731865 | 0.91 | PIK3CA (0.72) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL25494702 | 0.90 | PIK3CA (0.66) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL25495064 | 0.89 | PIK3CA (0.61) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL627675 | 0.88 | PIK3CA (0.77) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL15599518 | 0.87 | PIK3CA (0.74) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL25494703 | 0.86 | PIK3CD (0.62) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL729624 | 0.86 | PIK3CA (0.74) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL25494638 | 0.85 | PIK3CD (0.67) | PIK3CAPIK3CDMTORPIK3CGPI4KA | |
| Omipalisib SCHEMBL623194 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| Omipalisib SCHEMBL29358168 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488184-A1 | COMBINATION | GlaxoSmithKline LLC (US) | 2012-08-22 | — | — | EP | claimed |
| EP-2482819-A2 | COMBINATION | GlaxoSmithKline LLC (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011046894-A1 | COMBINATION | GLAXOSMITHKLINE LLC (US) | 2011-04-21 | — | — | WO | claimed |
| WO-2011038380-A2 | COMBINATION | GLAXOSMITHKLINE LLC (US) | 2011-03-31 | — | — | WO | claimed |
| EP-2603078-A1 | COMBINATION | GlaxoSmithKline LLC (US) | 2013-06-19 | — | — | EP | disclosed |
| CN-102665720-A | Combination | GLAXOSMITHKLINE LLC | 2012-09-12 | — | — | CN | disclosed |
| EP-2488184-A1 | COMBINATION | GlaxoSmithKline LLC (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2488184-A1 | COMBINATION | GlaxoSmithKline LLC (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2482819-A2 | COMBINATION | GlaxoSmithKline LLC (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2012021480-A1 | COMBINATION | GLAXOSMITHKLINE LLC (US) | 2012-02-16 | — | — | WO | disclosed |
| WO-2011046894-A1 | COMBINATION | GLAXOSMITHKLINE LLC (US) | 2011-04-21 | — | — | WO | disclosed |
| WO-2011046894-A1 | COMBINATION | GLAXOSMITHKLINE LLC (US) | 2011-04-21 | — | — | WO | disclosed |
| WO-2011038380-A2 | COMBINATION | GLAXOSMITHKLINE LLC (US) | 2011-03-31 | — | — | WO | disclosed |