Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 18/20 | 1.00 |
| ▸ | CDK2 | P24941 | 17/20 | 1.00 |
| ▸ | CDK5R1 | Q15078 | 17/20 | 1.00 |
| ▸ | CCNA2 | P20248 | 16/20 | 1.00 |
| ▸ | CCNA1 | P78396 | 15/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 15/20 | 1.00 |
| ▸ | CDK1 | P06493 | 3/20 | 0.75 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.75 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.75 |
| ▸ | CDK7 | P50613 | 2/20 | 0.75 |
| ▸ | CCNH | P51946 | 2/20 | 0.75 |
| ▸ | CDK4 | P11802 | 1/20 | 0.75 |
| ▸ | CCND1 | P24385 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | CCNK | O75909 | 1/20 | 0.70 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6245433 | 1.00 | CDK5 (1.00) | CDK5CDK2CDK5R1CCNA2CCNA1 | |
| SCHEMBL22651813 | 0.91 | CDK5 (0.83) | CDK5CDK2CDK5R1CCNA2CCNA1 | |
| SCHEMBL4501614 | 0.86 | CDK2 (1.00) | CDK5CDK2CDK5R1CCNA2CCNA1 | |
| SCHEMBL3877470 | 0.86 | CDK2 (1.00) | CDK5CDK2CDK5R1CCNA2CCNA1 | |
| SCHEMBL25001230 | 0.85 | CDK2 (0.83) | CDK5CDK2CDK5R1CCNA2CCNA1 | |
| SCHEMBL4502860 | 0.84 | CDK2 (1.00) | CDK5CDK2CDK5R1CCNA2CCNA1 | |
| SCHEMBL4502851 | 0.84 | CDK2 (1.00) | CDK5CDK2CDK5R1CCNA2CCNA1 | |
| SCHEMBL28453367 | 0.84 | CDK5 (0.80) | CDK5CDK2CDK5R1CCNA2CCNA1 | |
| SCHEMBL28453366 | 0.84 | CDK5 (0.80) | CDK5CDK2CDK5R1CCNA2CCNA1 | |
| SCHEMBL13638194 | 0.83 | CDK5 (0.76) | CDK5CDK2CDK5R1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399446-B1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LTD (GB) | 2005-08-03 | — | — | EP | disclosed |