Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.61 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.61 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646839 | 1.00 | DPP4 (0.61) | DPP4DPP9DPP8PGRPREP | |
| SCHEMBL647393 | 0.87 | DPP4 (0.58) | DPP4DPP9DPP8PGR | |
| SCHEMBL645802 | 0.85 | DPP4 (0.75) | DPP4DPP9DPP8 | |
| SCHEMBL648354 | 0.84 | DPP4 (0.68) | DPP4DPP9DPP8 | |
| SCHEMBL6508986 | 0.84 | DPP4 (0.68) | DPP4DPP9DPP8 | |
| SCHEMBL648116 | 0.83 | DPP4 (0.62) | DPP4DPP9DPP8 | |
| SCHEMBL647636 | 0.83 | DPP4 (0.62) | DPP4DPP9DPP8 | |
| SCHEMBL4703708 | 0.83 | DPP4 (0.68) | DPP4DPP9DPP8 | |
| SCHEMBL646737 | 0.83 | DPP4 (0.64) | DPP4DPP9DPP8 | |
| SCHEMBL648643 | 0.83 | DPP4 (0.68) | DPP4DPP9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560811-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | Abbott Laboratories (US) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004026822-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2004-04-01 | — | — | WO | disclosed |