Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.81 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.81 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714534 | 1.00 | PDE4A (0.81) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4714537 | 1.00 | PDE4A (0.81) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4714154 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4714591 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4714155 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4717179 | 0.89 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4714013 | 0.87 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4714011 | 0.87 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4715350 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL4715348 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565464-A1 | 4-OXO-1-(3-SUBSTITUTED PHENYL-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDE PHOSPHODIESTERASE-4 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048374-A1 | 4-OXO-1-(3-SUBSTITUTED PHENYL-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-06-10 | — | — | WO | disclosed |