Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 9/20 | 0.55 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6248955 | 1.00 | DPP4 (0.55) | DPP4DPP7KCNH2EPHX1AAK1 | |
| SCHEMBL6360353 | 0.89 | DPP4 (0.44) | DPP4DPP7KCNH2AAK1DPP8 | |
| SCHEMBL6359699 | 0.89 | DPP4 (0.44) | DPP4DPP7KCNH2AAK1DPP8 | |
| SCHEMBL6360357 | 0.89 | DPP4 (0.44) | DPP4DPP7KCNH2AAK1DPP8 | |
| SCHEMBL6698692 | 0.85 | DPP4 (0.51) | DPP4DPP7EPHX1AAK1HDAC4 | |
| SCHEMBL6698698 | 0.85 | DPP4 (0.51) | DPP4DPP7EPHX1AAK1HDAC4 | |
| SCHEMBL27348045 | 0.83 | CALCRL (0.41) | DPP4DPP7EPHX1AAK1HDAC4 | |
| SCHEMBL12463556 | 0.82 | EPHX1 (0.45) | EPHX1AAK1HDAC4HDAC1HDAC6 | |
| SCHEMBL22501529 | 0.82 | EPHX1 (0.45) | EPHX1AAK1HDAC4HDAC1HDAC6 | |
| SCHEMBL13412185 | 0.80 | DPP4 (0.43) | DPP4DPP7KCNH2DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565437-A1 | DIPEPTIDYL PEPTIDASE IV INHIBITING FLUORINATED CYCLIC AMIDES | Pfizer Products Inc. (US) | 2005-08-24 | — | — | EP | disclosed |
| US-20040110817-A1 | Dipeptidyl peptidase IV inhibiting fluorinated cyclic amides | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
| WO-2004046106-A1 | DIPEPTIDYL PEPTIDASE IV INHIBITING FLUORINATED CYCLIC AMIDES | PFIZER PRODUCTS INC. (US) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110817-A1 | Dipeptidyl peptidase IV inhibiting fluorinated cyclic amides | DPP4, ALPI, DPP7 | DPP4 1/4885DPP7 3/4885KCNH2 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.