Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.56 |
| ▸ | IGF1R | P08069 | 17/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 16/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | PAK4 | O96013 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | INSR | P06213 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | LYN | P07948 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6249516 | 0.92 | EGFR (0.54) | EGFRIGF1RERBB4KDRAURKB | |
| SCHEMBL5813839 | 0.92 | EGFR (0.60) | EGFRIGF1RERBB4KDRAURKB | |
| SCHEMBL4826494 | 0.88 | EGFR (0.72) | EGFRIGF1RERBB4KDRAURKB | |
| SCHEMBL6271813 | 0.86 | EGFR (0.51) | EGFRIGF1RERBB4KDRAURKB | |
| SCHEMBL6262161 | 0.86 | EGFR (0.58) | EGFRIGF1RERBB4KDRAURKB | |
| SCHEMBL6276338 | 0.86 | EGFR (0.52) | EGFRIGF1RERBB4KDRAURKB | |
| SCHEMBL6271016 | 0.82 | EGFR (0.51) | EGFRIGF1RERBB4KDRAURKB | |
| SCHEMBL4826564 | 0.82 | EGFR (0.70) | EGFRIGF1RERBB4KDRAURKB | |
| SCHEMBL6430949 | 0.82 | EGFR (0.70) | EGFRIGF1RERBB4KDRAURKB | |
| SCHEMBL4827526 | 0.82 | EGFR (0.70) | EGFRIGF1RERBB4KDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379528-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH (DE) | 2005-12-07 | — | — | EP | disclosed |
| EP-1379528-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GmbH (DE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002076986-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-03 | — | — | WO | disclosed |