Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 18/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 18/20 | 0.66 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.66 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18000666 | 0.84 | FGFR4 (0.71) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL18004295 | 0.82 | FGFR1 (0.68) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL18003765 | 0.82 | FGFR4 (0.68) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL4405404 | 0.82 | FGFR1 (0.55) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL18004286 | 0.81 | FGFR1 (0.67) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL7857067 | 0.81 | FGFR4 (0.45) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL18010528 | 0.80 | FGFR1 (1.00) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL18004374 | 0.79 | FGFR4 (0.64) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL18004379 | 0.79 | FGFR4 (0.64) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL18000518 | 0.78 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549651-A1 | KINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011465-A1 | KINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-05 | — | — | WO | disclosed |