Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amlodipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.98 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.98 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.98 |
| ▸ | HTR1A | P08908 | 2/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.98 |
| ▸ | DRD1 | P21728 | 2/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.98 |
| ▸ | DRD3 | P35462 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.98 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.98 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.98 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.98 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levamlodipine SCHEMBL6250283 | 1.00 | TBXA2R (0.98) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 | |
| Levamlodipine SCHEMBL3227613 | 0.99 | TBXA2R (0.96) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 | |
| Amlodipine SCHEMBL29664887 | 0.99 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 | |
| Levamlodipine SCHEMBL30994756 | 0.99 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 | |
| Amlodipine SCHEMBL29397019 | 0.99 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 | |
| SCHEMBL29599419 | 0.99 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 | |
| Amlodipine SCHEMBL1816641 | 0.99 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 | |
| Amlodipine SCHEMBL26478 | 0.99 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 | |
| SCHEMBL13097922 | 0.99 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 | |
| Levamlodipine SCHEMBL41283 | 0.99 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ADORA3ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005089353-A2 | (S)-AMLODIPINE MALATE | SEPRACOR INC. (US) | 2005-09-29 | — | — | WO | disclosed |
| EP-0993447-B1 | A PROCESS FOR THE PREPARATION OF AMLODIPINE BENZENESULPHONATE | ADAMED SP ZOO (PL) | 2005-08-17 | — | — | EP | disclosed |
| EP-0993447-A1 | A PROCESS FOR THE PREPARATION OF AMLODIPINE BENZENESULPHONATE | Adamed SP. Z O.O. (PL) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999052873-A1 | A PROCESS FOR THE PREPARATION OF AMLODIPINE BENZENESULPHONATE | ADAMED SP. Z O.O. (PL) | 1999-10-21 | — | — | WO | disclosed |