Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.70 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | EEF2K | O00418 | 1/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775711 | 0.88 | BRAF (0.81) | BRAFHSP90AB1ALDH1A1LIMK1MEN1 | |
| SCHEMBL6258124 | 0.87 | BRAF (0.79) | BRAFHSP90AB1ALDH1A1EEF2KMEN1 | |
| SCHEMBL1775859 | 0.83 | BRAF (0.70) | BRAFHSP90AB1ALDH1A1EEF2KMEN1 | |
| SCHEMBL1776805 | 0.83 | BRAF (0.77) | BRAFHSP90AB1ALDH1A1EEF2KLIMK1 | |
| SCHEMBL6257937 | 0.82 | BRAF (0.83) | BRAFHSP90AB1ALDH1A1EEF2KMEN1 | |
| SCHEMBL1776085 | 0.82 | BRAF (1.00) | BRAFHSP90AB1ALDH1A1EEF2KLIMK1 | |
| SCHEMBL6253458 | 0.82 | BRAF (0.69) | BRAFHSP90AB1ALDH1A1EEF2KMEN1 | |
| SCHEMBL6256957 | 0.82 | BRAF (0.69) | BRAFHSP90AB1ALDH1A1EEF2KMEN1 | |
| SCHEMBL6255310 | 0.81 | BRAF (0.74) | BRAFHSP90AB1ALDH1A1EEF2KMEN1 | |
| SCHEMBL6254816 | 0.81 | BRAF (0.81) | BRAFHSP90AB1ALDH1A1EEF2KMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058315-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS IKK2 INHIBITORS WITH ANTI-HBV ACTIVITY | RIBAPHARM, INC. (US) | 2005-06-30 | — | — | WO | disclosed |