Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.74 |
| ▸ | MPC2 | O95563 | 2/20 | 0.74 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | RXRA | P19793 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625384 | 1.00 | PPARG (0.74) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL18541503 | 0.85 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL622605 | 0.85 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL18538169 | 0.85 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL18541482 | 0.85 | PPARG (1.00) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| SCHEMBL11929116 | 0.84 | PPARG (0.76) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| SCHEMBL10085212 | 0.84 | PPARG (0.79) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| Mitoglitazone SCHEMBL2221702 | 0.84 | PPARG (0.98) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| SCHEMBL10119002 | 0.84 | PPARG (0.79) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| SCHEMBL14408626 | 0.83 | PPARG (0.78) | PPARGMPC2CYP2C8CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603507-B1 | SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEV CO LLC (US) | 2016-06-29 | — | — | EP | disclosed |
| US-8946435-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946435-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140378687-A1 | Synthesis for Thiazolidinedione Compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC | 2014-12-25 | — | — | US | disclosed |
| US-20140378687-A1 | Synthesis for Thiazolidinedione Compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC | 2014-12-25 | — | — | US | disclosed |
| US-8895748-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2014-11-25 | — | — | US | disclosed |
| US-8895748-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2014-11-25 | — | — | US | disclosed |
| US-20130211092-A1 | SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEVELOPMENT COMPANY LLC (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130211092-A1 | SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEVELOPMENT COMPANY LLC (US) | 2013-08-15 | — | — | US | disclosed |
| EP-2603507-A1 | SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | Metabolic Solutions Development Company LLC (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021467-A1 | SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130211092-A1 | SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | PPARD, PPARG, PPARA | PPARG 2/4885MPC2 273/4885CYP2C8 389/4885 |
| US-20140378687-A1 | Synthesis for Thiazolidinedione Compounds | PPARD, PPARG, PPARA | PPARG 2/4885MPC2 273/4885CYP2C8 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.