Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6254149 | 1.00 | CHRM1 (0.47) | CHRM1HRH1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL4843878 | 0.94 | CHRM1 (0.42) | CHRM1HRH1PAK1DRD2DRD4 | |
| Succinic Acid SCHEMBL4843873 | 0.94 | CHRM1 (0.42) | CHRM1HRH1PAK1DRD2DRD4 | |
| SCHEMBL14156711 | 0.86 | CHRM1 (0.47) | CHRM1HRH1PAK1DRD2DRD4 | |
| SCHEMBL14156710 | 0.86 | CHRM1 (0.47) | CHRM1HRH1PAK1DRD2DRD4 | |
| SCHEMBL4845304 | 0.86 | CHRM1 (0.40) | CHRM1HRH1PAK1DRD2DRD4 | |
| SCHEMBL14156704 | 0.83 | CHRM1 (0.56) | CHRM1HRH1PAK1DRD2DRD4 | |
| SCHEMBL4844077 | 0.82 | CHRM1 (0.42) | CHRM1HRH1PAK1DRD2DRD4 | |
| SCHEMBL4836972 | 0.82 | CHRM1 (0.42) | CHRM1HRH1PAK1DRD2DRD4 | |
| SCHEMBL4843467 | 0.82 | CHRM1 (0.46) | CHRM1HRH1PAK1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546134-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | ELI LILLY AND COMPANY (US) | 2005-06-29 | — | — | EP | claimed |
| WO-2004014895-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | claimed |
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |