Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.89 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.89 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.89 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.89 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.50 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Awd-12-281 SCHEMBL29413256 | 0.94 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| Awd-12-281 SCHEMBL155120 | 0.94 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| Awd-12-281 SCHEMBL5638136 | 0.93 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| Awd-12-281 SCHEMBL5638122 | 0.93 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL13111734 | 0.88 | PDE4B (0.73) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3101476 | 0.88 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL5636420 | 0.86 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5637135 | 0.86 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL5637675 | 0.86 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL5636589 | 0.85 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116501-A1 | Treatment of nonallergic rhinitis by selective phosphodiesterase 4 inhibitors | ELBION AG (DE) | 2004-06-17 | — | — | US | claimed |
| EP-1534272-A2 | TREATMENT OF NON-ALLERGIC RHINITIS BY MEANS OF SELECTIVE PHOSPHODIESTERASE-4 INHIBITORS | Elbion AG (DE) | 2005-06-01 | — | — | EP | disclosed |
| US-20040116501-A1 | Treatment of nonallergic rhinitis by selective phosphodiesterase 4 inhibitors | ELBION AG (DE) | 2004-06-17 | — | — | US | disclosed |
| WO-2004022041-A2 | TREATMENT OF NON-ALLERGIC RHINITIS BY MEANS OF SELECTIVE PHOSPHODIESTERASE-4 INHIBITORS | ELBION AG (DE) | 2004-03-18 | — | — | WO | disclosed |