Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 14/20 | 0.69 |
| ▸ | KDR | P35968 | 12/20 | 0.69 |
| ▸ | FLT1 | P17948 | 11/20 | 0.69 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256018 | 1.00 | TEK (0.69) | TEKKDRFLT1NR1I3GRM4 | |
| SCHEMBL4767249 | 0.94 | TEK (0.74) | TEKKDRFLT1GRM4 | |
| SCHEMBL4767246 | 0.94 | TEK (0.74) | TEKKDRFLT1GRM4 | |
| SCHEMBL4774625 | 0.88 | TEK (0.80) | TEKKDRFLT1NR1I3GRM4 | |
| SCHEMBL4774631 | 0.88 | TEK (0.80) | TEKKDRFLT1NR1I3GRM4 | |
| SCHEMBL4764883 | 0.82 | TEK (1.00) | TEKKDRFLT1GRM4 | |
| SCHEMBL4764887 | 0.82 | TEK (1.00) | TEKKDRFLT1GRM4 | |
| SCHEMBL4774488 | 0.81 | TEK (1.00) | TEKKDRFLT1GRM4 | |
| SCHEMBL4774486 | 0.81 | TEK (1.00) | TEKKDRFLT1GRM4 | |
| SCHEMBL4765010 | 0.79 | TEK (0.64) | TEKKDRFLT1NR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575963-A1 | THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058776-A1 | THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |