Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6255806 | 0.87 | POLB (0.56) | POLBHPGDRECQLADORA2AHTT | |
| SCHEMBL5354719 | 0.84 | POLB (0.51) | POLBHPGDRECQLADORA2AHTT | |
| SCHEMBL5363528 | 0.77 | POLB (0.54) | POLBHPGDRECQLADORA2AHTT | |
| SCHEMBL5366362 | 0.76 | HSD17B2 (0.54) | ADORA2AHSD17B2HSD17B1AOC3LMNA | |
| SCHEMBL5362664 | 0.71 | HSD17B2 (0.42) | ADORA2AHSD17B2HSD17B1AOC3LMNA | |
| SCHEMBL5359847 | 0.70 | HSD17B2 (0.59) | ADORA2AHSD17B2HSD17B1SIRT2PDK1 | |
| SCHEMBL5365662 | 0.70 | HPGD (0.50) | POLBHPGDRECQLHTTHSD17B2 | |
| SCHEMBL5359222 | 0.70 | AOC3 (0.46) | HPGDAOC3LMNATP53MAPT | |
| SCHEMBL5358809 | 0.67 | NR1H4 (0.45) | ADORA2AHSD17B2HSD17B1SIRT2AOC3 | |
| SCHEMBL3945114 | 0.66 | AOC3 (0.49) | POLBHPGDRECQLHTTHSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572629-A1 | COMPOUNDS WHICH MODULATE PPARϝ TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | Galderma Research & Development, S.N.C. (FR) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004052840-A1 | COMPOUNDS WHICH MODULATE PPARϜ TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-06-24 | — | — | WO | disclosed |