⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302044 | 0.82 | — | — | |
| SCHEMBL8769739 | 0.82 | — | — | |
| SCHEMBL7667 | 0.79 | — | — | |
| SCHEMBL15641693 | 0.76 | — | — | |
| SCHEMBL5986850 | 0.76 | — | — | |
| SCHEMBL5986216 | 0.73 | — | — | |
| SCHEMBL10894658 | 0.73 | HMGCR (0.48) | — | |
| SCHEMBL5915241 | 0.71 | — | — | |
| SCHEMBL5985939 | 0.69 | — | — | |
| SCHEMBL2206246 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949575-B2 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives | PFIZER INC. (US) | 2005-09-27 | — | — | US | disclosed |
| EP-1284958-B1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING AMINOIDANE DERIVATIVES | WARNER LAMBERT CO (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20030220382-A1 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives | BARTA NANCY SUE (US) | 2003-11-27 | — | — | US | disclosed |
| EP-1284958-A1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING AMINOIDANE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2003-02-26 | — | — | EP | disclosed |
| WO-2001083425-A1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING AMINOINDANE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-08 | — | — | WO | disclosed |