Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 10/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | ACTR2 | P61160 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5971697 | 1.00 | CCR1 (0.58) | CCR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL2932864 | 1.00 | CCR1 (0.58) | CCR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL6076924 | 0.89 | CCR1 (0.58) | CCR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL6077406 | 0.88 | CCR1 (0.57) | CCR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL6246788 | 0.84 | CCR1 (0.61) | CCR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5066097 | 0.84 | CCR1 (0.67) | CCR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5066100 | 0.84 | CCR1 (0.67) | CCR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5066103 | 0.84 | CCR1 (0.67) | CCR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5056094 | 0.81 | CCR1 (0.66) | CCR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5056092 | 0.81 | CCR1 (0.66) | CCR1PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572704-A1 | PHOSPHORUS-CONTAINING PIPERAZINE DERIVATIVES AS CCR1 ANTAGONISTS | Pfizer Products Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004055031-A1 | PHOSPHORUS-CONTAINING PIPERAZINE DERIVATIVES AS CCR1 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2004-07-01 | — | — | WO | disclosed |