Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.32 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646193 | 0.85 | GCK (0.57) | GCKKCNH2USP2LMNAMEN1 | |
| SCHEMBL2646344 | 0.85 | GCK (0.57) | GCKKCNH2USP2LMNAMEN1 | |
| SCHEMBL2646194 | 0.85 | GCK (0.57) | GCKKCNH2USP2LMNAMEN1 | |
| SCHEMBL2646340 | 0.85 | GCK (0.57) | GCKKCNH2USP2LMNAMEN1 | |
| SCHEMBL2646710 | 0.85 | GCK (0.41) | GCKPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL2646581 | 0.85 | GCK (0.41) | GCKPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL2646583 | 0.85 | GCK (0.41) | GCKPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL2646712 | 0.85 | GCK (0.41) | GCKPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL2646184 | 0.81 | NPC1 (0.39) | GCKPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL2646181 | 0.81 | NPC1 (0.39) | GCKPIK3CDPIK3CAPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242397-B1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |