Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 0.45 |
| ▸ | CCR1 | P32246 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6257518 | 0.92 | TACR1 (0.54) | TACR1CCR1HTTKDM4EMEN1 | |
| SCHEMBL6263440 | 0.88 | CCR1 (0.43) | TACR1CCR1HTTKDM4EMEN1 | |
| SCHEMBL6259791 | 0.88 | CCR1 (0.39) | TACR1CCR1HTTKDM4EMEN1 | |
| SCHEMBL5394686 | 0.87 | TACR1 (0.44) | TACR1SMN1; SMN2 | |
| SCHEMBL6261488 | 0.87 | TACR1 (0.61) | TACR1 | |
| SCHEMBL6264225 | 0.83 | TACR1 (0.51) | TACR1CCR1TACR3P2RX7 | |
| SCHEMBL6258643 | 0.83 | TACR1 (0.54) | TACR1CCR1 | |
| SCHEMBL5389958 | 0.80 | TACR1 (0.52) | TACR1 | |
| SCHEMBL6261284 | 0.80 | CCR1 (0.46) | TACR1CCR1 | |
| SCHEMBL6262695 | 0.79 | TACR1 (0.47) | TACR1CCR1P2RX7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423117-B1 | 2-SUBSTITUTED 1-ARYLPIPERAZINES AS TACHYKININ ANTAGONISTS AND/OR SEROTONIN REUPTAKE INHIBITORS | GLAXO GROUP LTD (GB) | 2005-10-19 | — | — | EP | disclosed |