⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9583242 | 1.00 | — | — | |
| SCHEMBL13381684 | 1.00 | — | — | |
| SCHEMBL30360356 | 1.00 | — | — | |
| SCHEMBL8607882 | 1.00 | — | — | |
| SCHEMBL9583252 | 1.00 | — | — | |
| SCHEMBL30360325 | 1.00 | — | — | |
| SCHEMBL692812 | 0.92 | CYSLTR2 (0.57) | — | |
| SCHEMBL4300160 | 0.92 | CYSLTR2 (0.57) | — | |
| SCHEMBL692811 | 0.92 | CYSLTR2 (0.57) | — | |
| SCHEMBL3356855 | 0.92 | CYSLTR2 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185517-B1 | PROCESS FOR PREPARING A LEUKOTRIENE ANTAGONIST AND AN INTERMEDIATE THEREOF | MOEHS IBERICA SL (ES) | 2012-09-19 | — | — | EP | disclosed |
| WO-2012077133-A1 | PROCESSES FOR PREPARATION OF MONTELUKAST SODIUM AND PURIFICATION OF DIOL INTERMEDIATE | IND-SWIFT LABORATORIES LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |
| US-8163924-B2 | Process for preparing a leukotriene antagonist and an intermediate thereof | Moehs Ibérica, S.L. (ES) | 2012-04-24 | — | — | US | disclosed |
| US-8163924-B2 | Process for preparing a leukotriene antagonist and an intermediate thereof | Moehs Ibérica, S.L. (ES) | 2012-04-24 | — | — | US | disclosed |
| WO-2012020271-A1 | PROCESS FOR THE PREPARATION OF MONTELUKAST SODIUM | RICHTER GEDEON NYRT. (HU) | 2012-02-16 | — | — | WO | disclosed |
| US-8115004-B2 | Process for pure montelukast sodium through pure intermediates as well as amine salts | MSN LABORATORIES LIMITED (IN) | 2012-02-14 | — | — | US | disclosed |
| US-20100204476-A1 | Process for preparing a leukotriene antagonist and an intermediate thereof | MOEHS IBERICA S.L. (ES) | 2010-08-12 | — | — | US | disclosed |
| US-20100204476-A1 | Process for preparing a leukotriene antagonist and an intermediate thereof | MOEHS IBERICA S.L. (ES) | 2010-08-12 | — | — | US | disclosed |
| US-20100081688-A1 | Process for the preparation of montelukast, and intermediates therefor | CIPLA LIMITED (IN) | 2010-04-01 | — | — | US | disclosed |
| US-20100056793-A1 | PROCESS FOR PURE MONTELUKAST SODIUM THROUGH PURE INTERMEDIATES AS WELL AS NOVEL AMINE SALTS | MSN LABORATORIES LIMITED (IN) | 2010-03-04 | — | — | US | disclosed |
| WO-2009016191-A1 | PROCESS FOR PREPARING A LEUKOTRIENE ANTAGONIST AND AN INTERMEDIATE THEREOF | Moehs Ibérica, S.L. (ES) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008058118-A2 | PREPARATION OF MONTELUKAST AND ITS SALTS | DR. REDDY'S LABORTORIES, LTD. (IN) | 2008-05-15 | — | — | WO | disclosed |
| US-7189853-B2 | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts | DR. REDDY'S LABORATORIES LIMITED (IN) | 2007-03-13 | — | — | US | disclosed |
| EP-0971587-B1 | QUINOLINE LEUKOTRIENE ANTAGONISTS | MERCK & CO INC (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-0971587-A4 | QUINOLINE LEUKOTRIENE ANTAGONISTS | MERCK & CO INC (US) | 2004-08-04 | — | — | EP | disclosed |
| EP-0971587-A1 | QUINOLINE LEUKOTRIENE ANTAGONISTS | Merck & Co., Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998039970-A1 | QUINOLINE LEUKOTRIENE ANTAGONISTS | MERCK & CO., INC. (US) | 1998-09-17 | — | — | WO | disclosed |
| US-5750539-A | ANTIASTHMATICS | MERCK FROSST CANADA (CA) | 1998-05-12 | — | — | US | disclosed |