Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 6/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6261967 | 0.81 | HRH3 (0.51) | HRH3HRH1FAAHJAK2JAK1 | |
| SCHEMBL3089295 | 0.76 | HRH3 (0.55) | HRH3HRH1JAK2JAK1JAK3 | |
| SCHEMBL3333692 | 0.76 | PDE4B (0.47) | HRH3HRH1FAAH | |
| SCHEMBL1873259 | 0.73 | HRH3 (0.64) | HRH3HRH1JAK2JAK1JAK3 | |
| SCHEMBL3089288 | 0.72 | HRH3 (0.80) | HRH3HRH1 | |
| SCHEMBL4404051 | 0.68 | HRH3 (0.57) | HRH3HRH1FAAH | |
| SCHEMBL3077662 | 0.68 | HRH3 (0.52) | HRH3HRH1JAK2JAK3 | |
| SCHEMBL22847887 | 0.68 | PDE4B (0.61) | — | |
| SCHEMBL26077668 | 0.68 | PDE4B (0.48) | HRH3HRH1 | |
| SCHEMBL3077258 | 0.67 | HRH3 (0.67) | HRH3HRH1JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572215-A1 | BENZO[D]AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056369-A1 | BENZO ‘ D!AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-07-08 | — | — | WO | disclosed |