Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4832143 | 0.87 | MEN1 (0.36) | KCNH2MEN1USP2KMT2ANAMPT | |
| SCHEMBL4832827 | 0.85 | AURKA (0.34) | KDRFLT1MEN1KMT2AGAA | |
| SCHEMBL1385832 | 0.84 | KDR (0.39) | KCNH2KDRPDGFRBKITFLT1 | |
| SCHEMBL1386447 | 0.82 | AURKA (0.37) | KDRGAASMN1; SMN2 | |
| SCHEMBL1383874 | 0.82 | KDR (0.41) | KDRPDGFRBKITFLT1MEN1 | |
| SCHEMBL1385506 | 0.80 | KDR (0.44) | KCNH2KDRPDGFRBKITFLT1 | |
| SCHEMBL1385057 | 0.79 | KDR (0.46) | KDRPDGFRBKITFLT1GAA | |
| SCHEMBL1385569 | 0.77 | PIK3CD (0.38) | KCNH2KDRMEN1USP2KMT2A | |
| SCHEMBL1386153 | 0.75 | KDR (0.31) | KDRPDGFRBKITFLT1GAA | |
| SCHEMBL1382757 | 0.74 | PIK3CG (0.41) | KCNH2KDRMEN1USP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254138-B1 | PYRIDINE DERIVATIVES INHIBITING ANGIOGENESIS AND/OR VEGF RECEPTOR TYROSINE KINASE | NOVARTIS AG (CH) | 2005-05-11 | — | — | EP | claimed |