Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 1.00 |
| ▸ | CA9 | Q16790 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15335372 | 0.84 | KMT2A (1.00) | CA12CA9KMT2APOLBGBA1 | |
| SCHEMBL27696165 | 0.79 | CA12 (0.65) | CA12CA9KMT2APOLBKDM4E | |
| SCHEMBL10036520 | 0.78 | KMT2A (0.67) | CA12CA9KMT2APOLBMEN1 | |
| SCHEMBL15843191 | 0.78 | KMT2A (0.74) | CA12CA9KMT2APOLBGBA1 | |
| SCHEMBL6264767 | 0.78 | CA9 (1.00) | CA12CA9KMT2APOLBSRD5A1 | |
| SCHEMBL6265592 | 0.77 | KDM4E (0.70) | CA12CA9KMT2APOLBMCL1 | |
| SCHEMBL15842550 | 0.77 | CA9 (0.75) | CA12CA9KMT2APOLBGBA1 | |
| SCHEMBL29468148 | 0.76 | KMT2A (0.68) | CA12CA9KMT2APOLBKDM4E | |
| SCHEMBL6268207 | 0.74 | CA9 (0.69) | CA12CA9KMT2APOLBMCL1 | |
| SCHEMBL7765549 | 0.74 | CA9 (0.69) | CA12CA9KMT2APOLBMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5455268-A | Treating arthropathy | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1995-10-03 | — | — | US | claimed |
| WO-2005091960-A2 | METHOD FOR INHIBITING FIBROCARTILAGE DEGRADATION | RUSH UNIVERSITY MEDICAL CENTER (US) | 2005-10-06 | — | — | WO | disclosed |
| US-6750249-B1 | GRADUALLY RELEASE ESCULETIN OR ITS DERIVATIVE IN A CONTROLLED MANNER OVER A LONG PERIOD OF TIME | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 2004-06-15 | — | — | US | disclosed |
| EP-1121931-A1 | CONTROLLED RELEASE ORAL PREPARATIONS OF ESCULETIN AND ITS DERIVATIVES | Kureha Chemical Industry Co., Ltd. (JP) | 2001-08-08 | — | — | EP | disclosed |
| EP-0614896-B1 | Esculetin derivatives and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 1998-12-30 | — | — | EP | disclosed |
| US-5455268-A | Treating arthropathy | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1995-10-03 | — | — | US | disclosed |
| EP-0614896-A1 | Esculetin derivatives and pharmaceutical composition | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1994-09-14 | — | — | EP | disclosed |