Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.59 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.59 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.59 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.59 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.59 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6263542 | 0.93 | MAP2K1 (0.58) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6266517 | 0.93 | MEN1 (0.65) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6260580 | 0.91 | MAP2K1 (0.62) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6268868 | 0.91 | MAP2K1 (0.57) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6262745 | 0.90 | MAP2K1 (0.56) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6264056 | 0.89 | MEN1 (0.51) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6261657 | 0.89 | MAP2K1 (0.58) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6262864 | 0.88 | MAP2K1 (0.57) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6266655 | 0.87 | MAP2K1 (0.59) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6262386 | 0.87 | MAP2K1 (0.59) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144371-B1 | BENZENESULPHONAMIDE DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2005-11-09 | — | — | EP | claimed |