Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627894 | 1.00 | EGLN1 (0.66) | EGLN1ADORA2AGLATSHRHSD17B10 | |
| SCHEMBL626735 | 1.00 | EGLN1 (0.66) | EGLN1ADORA2AGLATSHRHSD17B10 | |
| SCHEMBL627189 | 0.94 | EGLN1 (0.67) | EGLN1ADORA2A | |
| SCHEMBL16626167 | 0.92 | EGLN1 (0.68) | EGLN1GLAGAAHPGD | |
| SCHEMBL16626160 | 0.92 | EGLN1 (0.68) | EGLN1ADORA2A | |
| SCHEMBL627010 | 0.90 | EGLN1 (0.69) | EGLN1ADORA2A | |
| SCHEMBL21802967 | 0.83 | EGLN1 (0.62) | EGLN1ADORA2A | |
| SCHEMBL626312 | 0.83 | ADORA2A (0.54) | EGLN1ADORA2AGLATSHRHSD17B10 | |
| SCHEMBL626729 | 0.82 | EGLN1 (0.67) | EGLN1ADORA2A | |
| SCHEMBL16626253 | 0.81 | EGLN1 (0.67) | EGLN1ADORA2AGLATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006251-B2 | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors | JANSSEN PHARAMCEUTICA NV (BE) | 2015-04-14 | — | — | US | disclosed |
| EP-2603502-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021830-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-02-16 | — | — | WO | disclosed |