Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041983 | 0.85 | FLT3 (0.69) | FLT3JAK2TBK1 | |
| SCHEMBL2086457 | 0.85 | FLT3 (0.69) | FLT3JAK2TBK1 | |
| SCHEMBL4041009 | 0.70 | FLT3 (0.68) | FLT3JAK2 | |
| SCHEMBL2087674 | 0.70 | FLT3 (0.68) | FLT3JAK2 | |
| SCHEMBL4040469 | 0.67 | FLT3 (0.73) | FLT3JAK2PTK2 | |
| SCHEMBL4040180 | 0.67 | FLT3 (0.60) | FLT3JAK2 | |
| SCHEMBL2088943 | 0.67 | FLT3 (1.00) | FLT3CSNK2A1JAK2 | |
| SCHEMBL4044051 | 0.66 | FLT3 (0.62) | FLT3ABCB1ABCG2ABCC1JAK2 | |
| SCHEMBL4039295 | 0.66 | FLT3 (0.58) | FLT3JAK2 | |
| SCHEMBL24490436 | 0.62 | ABCG2 (0.59) | ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562589-A2 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046120-A2 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-06-03 | — | — | WO | disclosed |