Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 18/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.41 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | CALCA | P06881 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6265245 | 0.91 | CALCRL (0.41) | CALCRLCYP3A4RAMP1CALCA | |
| SCHEMBL6263478 | 0.91 | CALCRL (0.43) | CALCRLCYP3A4RAMP1 | |
| SCHEMBL3278367 | 0.91 | CALCRL (0.50) | CALCRLCYP3A4RAMP1CALCA | |
| SCHEMBL13303434 | 0.89 | CALCRL (0.49) | CALCRLCYP3A4RAMP1CALCA | |
| SCHEMBL3277723 | 0.83 | CALCRL (0.51) | CALCRLCYP3A4CALCA | |
| SCHEMBL6262515 | 0.82 | CALCRL (0.54) | CALCRLCYP3A4RAMP1 | |
| SCHEMBL3277767 | 0.82 | CALCRL (0.52) | CALCRLCYP3A4RAMP1CALCA | |
| SCHEMBL6227702 | 0.82 | CALCRL (0.40) | CALCRLCYP3A4RAMP1CALCA | |
| SCHEMBL6267533 | 0.82 | CALCRL (0.45) | CALCRLCYP3A4CALCA | |
| SCHEMBL3278176 | 0.78 | CALCRL (0.49) | CALCRLCYP3A4RAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558601-A1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-08-03 | — | — | EP | claimed |
| WO-2004037811-A1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-05-06 | — | — | WO | claimed |
| EP-1558601-A1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004037811-A1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-05-06 | — | — | WO | disclosed |