Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 16/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6266291 | 0.95 | PTPN1 (0.43) | NLRP3PTPN1PTPN2 | |
| SCHEMBL6263193 | 0.92 | PTPN1 (0.41) | NLRP3PTPN1PTPN2 | |
| SCHEMBL6267947 | 0.90 | PTPN1 (0.43) | NLRP3PTPN1PTPN2 | |
| SCHEMBL3916381 | 0.90 | PTPN1 (0.43) | PTPN1PTPN2 | |
| SCHEMBL3908638 | 0.88 | PTPN1 (0.48) | PTPN1PTPN2 | |
| SCHEMBL3907066 | 0.87 | PTPN1 (0.45) | PTPN1PTPN2 | |
| SCHEMBL6262985 | 0.86 | PTPN1 (0.42) | PTPN1PTPN2MAPK1 | |
| SCHEMBL3910263 | 0.85 | PTPN1 (0.46) | PTPN1PTPN2 | |
| SCHEMBL6263295 | 0.85 | PTPN1 (0.42) | PTPN1PTPN2 | |
| SCHEMBL3909708 | 0.84 | PTPN1 (0.41) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005081954-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |