SCHEMBL6269092

SCHEMBL6269092

Fc1ccc2c(c1)CC(CCN1CCC1)=C2Cc1cccnn1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 11/20 0.69
CYP2D6 P10635 9/20 0.69
KCNH2 Q12809 3/20 0.69
CHRM1 P11229 4/20 0.49
CYP3A4 P08684 2/20 0.39
DRD2 P14416 3/20 0.38
HTR2A P28223 3/20 0.38
SIGMAR1 Q99720 3/20 0.38
HTR1A P08908 2/20 0.38
DRD4 P21917 2/20 0.38
SLC6A4 P31645 2/20 0.38
HTR7 P34969 2/20 0.38
DRD3 P35462 2/20 0.38
HTR2C P28335 2/20 0.38
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
HRH3 Q9Y5N1 1/20 0.37
SLC6A3 Q01959 1/20 0.36
HTR2B P41595 1/20 0.35
CHRM2 P08172 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6269301 0.98 HRH1 (0.69) HRH1CYP2D6KCNH2CHRM1CYP3A4
SCHEMBL6273536 0.92 HRH1 (0.58) HRH1CYP2D6KCNH2CHRM1CYP3A4
SCHEMBL6276925 0.89 HRH1 (0.69) HRH1CYP2D6KCNH2CHRM1CYP3A4
SCHEMBL6418812 0.87 HRH1 (0.63) HRH1CYP2D6KCNH2CHRM1CYP3A4
SCHEMBL6272817 0.85 HRH1 (0.76) HRH1CYP2D6KCNH2CHRM1CYP3A4
SCHEMBL6272485 0.82 HRH1 (1.00) HRH1CYP2D6KCNH2CHRM1HTR2A
SCHEMBL30834706 0.80 HRH1 (0.84) HRH1CYP2D6KCNH2CHRM1CYP3A4
SCHEMBL6273848 0.78 HRH1 (0.66) HRH1CYP2D6KCNH2CHRM1
SCHEMBL6267134 0.78 HRH1 (0.57) HRH1CYP2D6KCNH2CHRM1CYP3A4
SCHEMBL6414658 0.77 CHRM1 (0.56) HRH1CYP2D6KCNH2CHRM1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005097093-A1 SLEEP INDUCING COMPOUNDS AND METHODS RELATING THERETO NEUROCRINE BIOSCIENCES, INC. (US) 2005-10-20 WO disclosed