Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 18/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626267 | 0.72 | GRM2 (0.54) | GRM2GAA | |
| SCHEMBL625991 | 0.72 | GRM2 (0.68) | GRM2GAANPC1LMNATSHR | |
| SCHEMBL9883723 | 0.69 | GRM2 (0.49) | GRM2TSHR | |
| SCHEMBL626723 | 0.69 | GRM2 (0.44) | GRM2 | |
| SCHEMBL626105 | 0.69 | GRM2 (0.47) | GRM2 | |
| SCHEMBL626450 | 0.68 | GRM2 (0.61) | GRM2 | |
| SCHEMBL626749 | 0.67 | GRM2 (0.43) | GRM2 | |
| SCHEMBL626002 | 0.65 | GRM2 (0.51) | GRM2 | |
| SCHEMBL13355035 | 0.65 | BRD4 (0.51) | GAANPC1LMNATSHRRAB9A | |
| SCHEMBL14992941 | 0.65 | GRM2 (0.57) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |