Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097113 | 1.00 | MDM2 (0.37) | MDM2SLC6A4SLC6A2SLC6A3TACR1 | |
| SCHEMBL6098050 | 1.00 | MDM2 (0.37) | MDM2SLC6A4SLC6A2SLC6A3TACR1 | |
| SCHEMBL6098052 | 1.00 | MDM2 (0.37) | MDM2SLC6A4SLC6A2SLC6A3TACR1 | |
| SCHEMBL6095480 | 0.92 | SLC6A4 (0.35) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6096900 | 0.92 | SLC6A4 (0.35) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6096896 | 0.92 | SLC6A4 (0.35) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6274831 | 0.92 | SLC6A4 (0.35) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6094715 | 0.91 | SLC6A4 (0.38) | MDM2SLC6A4SLC6A2SLC6A3HTR2C | |
| SCHEMBL6096643 | 0.91 | SLC6A4 (0.38) | MDM2SLC6A4SLC6A2SLC6A3HTR2C | |
| SCHEMBL6096640 | 0.91 | SLC6A4 (0.38) | MDM2SLC6A4SLC6A2SLC6A3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605941-A1 | SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-21 | — | — | EP | claimed |
| WO-2004080460-A1 | SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-23 | — | — | WO | claimed |