Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.69 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16626157 | 0.93 | EGLN1 (0.66) | EGLN1ADORA2AIRAK4MAPTMAPK1 | |
| SCHEMBL627243 | 0.85 | EGLN1 (0.69) | EGLN1ADORA2AMAOBHTR6 | |
| SCHEMBL623196 | 0.82 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL627572 | 0.81 | CYP1A2 (0.58) | EGLN1ADORA2AIRAK4MAPK1 | |
| SCHEMBL21802969 | 0.78 | EGLN1 (0.64) | EGLN1MAPTMAPK1HTTNPSR1 | |
| SCHEMBL16626233 | 0.77 | EGLN1 (0.67) | EGLN1ADORA2A | |
| SCHEMBL627146 | 0.77 | EGLN1 (0.67) | EGLN1ADORA2A | |
| SCHEMBL627593 | 0.77 | EGLN1 (0.69) | EGLN1ADORA2ADYRK1A | |
| SCHEMBL16626264 | 0.77 | EGLN1 (0.68) | EGLN1MAPTHTT | |
| SCHEMBL16626248 | 0.76 | EGLN1 (0.66) | EGLN1ADORA2AMAPTMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603502-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021830-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-02-16 | — | — | WO | disclosed |