Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627538 | 0.91 | EGLN1 (0.63) | EGLN1ADORA2A | |
| SCHEMBL627294 | 0.90 | EGLN1 (0.61) | EGLN1ADORA2A | |
| SCHEMBL14991882 | 0.80 | EGLN1 (0.51) | EGLN1ADORA2ARORC | |
| SCHEMBL14992354 | 0.80 | EGLN1 (0.65) | EGLN1ADORA2A | |
| SCHEMBL10227669 | 0.79 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL14992287 | 0.78 | EGLN1 (0.48) | EGLN1ADORA2A | |
| SCHEMBL14992348 | 0.76 | ADORA2A (0.46) | EGLN1ADORA2A | |
| SCHEMBL627376 | 0.76 | EGLN1 (0.64) | EGLN1ADORA2A | |
| SCHEMBL626955 | 0.74 | EGLN1 (0.65) | EGLN1ADORA2A | |
| SCHEMBL627068 | 0.74 | EGLN1 (0.67) | EGLN1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603502-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021830-A1 | 4 - AMINOQUINAZOLIN- 2 - YL - 1 - PYRRAZOLE - 4 - CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-02-16 | — | — | WO | disclosed |