Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.49 |
| ▸ | TNF | P01375 | 7/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | LYN | P07948 | 2/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 4/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | MUSK | O15146 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088475 | 0.87 | MAPK14 (0.53) | MAPK14TNFSRCABL1RAF1 | |
| SCHEMBL5988889 | 0.85 | TNF (0.33) | MAPK14TNF | |
| SCHEMBL7182315 | 0.84 | MAPK14 (0.51) | MAPK14TNFSRCABL1RAF1 | |
| SCHEMBL4081556 | 0.84 | MAPK14 (0.53) | MAPK14TNFSRCABL1RAF1 | |
| SCHEMBL4092259 | 0.82 | MAPK14 (0.51) | MAPK14TNFSRCABL1RAF1 | |
| SCHEMBL4095972 | 0.82 | MAPK14 (0.51) | MAPK14TNFSRCABL1RAF1 | |
| SCHEMBL4092852 | 0.82 | MAPK14 (0.51) | MAPK14TNFSRCABL1RAF1 | |
| SCHEMBL4082224 | 0.81 | MAPK14 (0.52) | MAPK14TNFSRCABL1RAF1 | |
| SCHEMBL4088478 | 0.80 | MAPK14 (0.53) | MAPK14TNFSRCABL1RAF1 | |
| SCHEMBL4096569 | 0.80 | MAPK14 (0.53) | MAPK14TNFSRCABL1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545514-A1 | ANTICOAGULANT AND FIBRINOLYTIC THERAPY USING P38 MAP KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004016267-A1 | ANTICOAGULANT AND FIBRINOLYTIC THERAPY USING P38 MAP KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-02-26 | — | — | WO | disclosed |