Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 13/20 | 0.45 |
| ▸ | SRC | P12931 | 5/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21579420 | 1.00 | EGFR (0.48) | EGFRJAK2JAK3BTKSRC | |
| SCHEMBL29063911 | 0.94 | SRC (0.49) | EGFRJAK2JAK3BTKSRC | |
| SCHEMBL26790961 | 0.94 | SRC (0.49) | EGFRJAK2JAK3BTKSRC | |
| SCHEMBL3849279 | 0.90 | KDR (0.44) | EGFRJAK2JAK3BTKSRC | |
| SCHEMBL21903722 | 0.89 | JAK2 (0.48) | EGFRJAK2JAK3BTKSRC | |
| SCHEMBL31684273 | 0.89 | JAK2 (0.48) | EGFRJAK2JAK3BTKSRC | |
| SCHEMBL22009062 | 0.89 | JAK2 (0.48) | EGFRJAK2JAK3BTKSRC | |
| SCHEMBL5820596 | 0.88 | SRC (0.44) | EGFRBTKSRCABL1PIK3CD | |
| SCHEMBL20645511 | 0.88 | BTK (0.45) | EGFRBTKSRCABL1PIK3CD | |
| SCHEMBL21903578 | 0.88 | BTK (0.46) | EGFRBTKSRCABL1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379528-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH (DE) | 2005-12-07 | — | — | EP | disclosed |
| EP-1379528-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GmbH (DE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002076986-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-03 | — | — | WO | disclosed |