Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14450046 | 0.85 | EPHB4 (0.50) | EPHB4AURKAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5489000 | 0.85 | EPHB4 (0.53) | EPHB4GSK3B | |
| SCHEMBL14450048 | 0.83 | EPHB4 (0.49) | EPHB4AURKAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14450047 | 0.82 | EPHB4 (0.52) | EPHB4HTTAURKAALDH1A1CYP1A2 | |
| SCHEMBL14450052 | 0.82 | EPHB4 (0.48) | EPHB4HTTAURKAALDH1A1CYP1A2 | |
| SCHEMBL13212660 | 0.82 | AURKA (0.64) | EPHB4AURKAALDH1A1KDM4E | |
| SCHEMBL8240272 | 0.81 | HTT (0.46) | HTTRXFP1AURKAALDH1A1CYP1A2 | |
| SCHEMBL23752231 | 0.79 | EPHB4 (0.53) | EPHB4AURKAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14450050 | 0.78 | EPHB4 (0.45) | EPHB4AURKAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29892881 | 0.77 | EPHB4 (0.49) | EPHB4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085252-A1 | IMIDAZO ‘1,2-A’ PYRAZINE COMPOUNDS WHICH INTERACT WITH PROTEIN KINASES | BIOFOCUS DISCOVERY LIMITED (GB) | 2005-09-15 | — | — | WO | disclosed |