Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | CCND1 | P24385 | 6/20 | 0.36 |
| ▸ | CDK4 | P11802 | 4/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626336 | 0.94 | TYK2 (0.39) | TYK2CCND1CDK4BTKCDK6 | |
| SCHEMBL610863 | 0.88 | CDK6 (0.41) | TYK2CCND1CDK4BTKCDK6 | |
| SCHEMBL607847 | 0.88 | CDK6 (0.41) | TYK2CCND1CDK4BTKCDK6 | |
| SCHEMBL611366 | 0.88 | CDK6 (0.41) | TYK2CCND1CDK4BTKCDK6 | |
| SCHEMBL609068 | 0.86 | CDK4 (0.45) | TYK2CCND1CDK4BTKCDK6 | |
| SCHEMBL612205 | 0.84 | FASN (0.40) | CCND1CDK4BTKDDB1CRBN | |
| SCHEMBL610349 | 0.83 | DDB1 (0.51) | DDB1CRBNCCNA2CDK2 | |
| SCHEMBL610780 | 0.83 | DDB1 (0.51) | DDB1CRBNCCNA2CDK2 | |
| SCHEMBL612067 | 0.83 | DDB1 (0.51) | DDB1CRBNCCNA2CDK2 | |
| SCHEMBL610280 | 0.82 | CDK6 (0.41) | TYK2CCND1CDK4BTKCDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603500-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012020008-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-16 | — | — | WO | disclosed |