Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | FGR | P09769 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16712573 | 0.90 | CHEK1 (0.52) | CHEK1BACE1NTRK1JAK2CSF1R | |
| SCHEMBL6397211 | 0.89 | CHEK1 (0.55) | CHEK1BACE1NTRK1CSF1RNTRK3 | |
| SCHEMBL4854682 | 0.87 | CHEK1 (0.64) | CHEK1BACE1NTRK1JAK2CSF1R | |
| SCHEMBL4859120 | 0.84 | CHEK1 (0.50) | CHEK1BACE1NTRK1JAK2CSF1R | |
| SCHEMBL6274689 | 0.78 | CHEK1 (0.58) | CHEK1BACE1 | |
| SCHEMBL16712639 | 0.78 | CHEK1 (0.46) | CHEK1JAK2CSF1RIKBKBKIT | |
| SCHEMBL4847679 | 0.77 | CHEK1 (0.58) | CHEK1BACE1CSF1RIKBKB | |
| SCHEMBL4883979 | 0.76 | CHEK1 (0.61) | CHEK1JAK2CSF1RIKBKBKIT | |
| SCHEMBL6273200 | 0.75 | CHEK1 (0.49) | CHEK1 | |
| SCHEMBL4857784 | 0.74 | CHEK1 (0.68) | CHEK1BACE1NTRK1CSF1RNTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004076424-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-10 | — | — | WO | disclosed |