SCHEMBL6279999

SCHEMBL6279999

Cc1cc(C(=O)CCCl)ccc1Cl

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
TAS1R3 Q7RTX0 1/20 0.45
TAS1R1 Q7RTX1 1/20 0.45
TAS1R2 Q8TE23 1/20 0.45
MCL1 Q07820 1/20 0.42
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
TSHR P16473 1/20 0.40
ALDH1A1 P00352 2/20 0.39
MAPT P10636 2/20 0.39
KMO O15229 1/20 0.39
MGAM O43451 1/20 0.39
AMY1A P0DUB6 1/20 0.39
GAA P10253 1/20 0.39
SI P14410 1/20 0.39
MGAM2 Q2M2H8 1/20 0.39
HDAC3 O15379 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21852336 0.85 MEN1 (0.47) TSHRALDH1A1MAPTGAA
SCHEMBL29816406 0.85 MEN1 (0.47) TSHRALDH1A1MAPTGAA
SCHEMBL2097486 0.85 GSK3B (0.53) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL24404054 0.84 KDM4E (0.54) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL11536711 0.84 KMT2A (0.58) CYP1A2CYP3A4CYP2C9CYP2C19MCL1
SCHEMBL11392489 0.83 TSHR (0.55) TSHRALDH1A1KMOHDAC3HDAC4
SCHEMBL29269279 0.82 ESR1 (0.41) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL2278168 0.81 CYP3A4 (0.52) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL27778655 0.81 CYP1A2 (0.52) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL10897477 0.80 HSD17B3 (0.57) CYP1A2CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6916838-B1 1-benzylpyrazole-3-carboxylic acid tricyclic derivatives as cannabinoid receptor antagonists SANOFI-AVENTIS (FR) 2005-07-12 US disclosed
EP-1230222-B1 1-BENZYLPYRAZOLES-3-CARBOXYLIC ACID TRICYCLIC DERIVATIVES AS CANNABINOID RECEPTOR ANTAGONISTS SANOFI SYNTHELABO (FR) 2004-07-07 EP disclosed
EP-1230222-A1 1-BENZYLPYRAZOLES-3-CARBOXYLIC ACID TRICYCLIC DERIVATIVES AS CANNABINOID RECEPTOR ANTAGONISTS SANOFI-SYNTHELABO (FR) 2002-08-14 EP disclosed
WO-2001032629-A1 1-BENZYLPYRAZOLES-3-CARBOXYLIC ACID TRICYCLIC DERIVATIVES AS CANNABINOID RECEPTOR ANTAGONISTS SANOFI-SYNTHELABO (FR) 2001-05-10 WO disclosed