Sugi Predict

Sugi Predict / Compounds / Pyrimidine

Pyrimidine

Pyrimidine

SCHEMBL6281859

CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc(SC)nc21.O=c1nccc[nH]1.c1cncnc1

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 18/20 0.51
▸ FGFR4 P22455 15/20 0.47
▸ FGFR2 P21802 6/20 0.47
▸ FGFR3 P22607 5/20 0.47
▸ KDR P35968 3/20 0.47
▸ KIT P10721 2/20 0.47
▸ NTRK1 P04629 1/20 0.46
▸ PDGFRB P09619 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4404764 0.87 FGFR1 (0.57) FGFR1FGFR4FGFR2FGFR3KDR
SCHEMBL4404529 0.72 FGFR1 (0.55) FGFR1FGFR4FGFR2FGFR3KDR
SCHEMBL15555670 0.72 FGFR1 (0.77) FGFR1FGFR4FGFR2FGFR3KDR
SCHEMBL4405404 0.72 FGFR1 (0.55) FGFR1FGFR4FGFR2FGFR3KDR
SCHEMBL4398695 0.71 FGFR4 (0.56) FGFR1FGFR4FGFR2FGFR3KDR
SCHEMBL4398327 0.71 FGFR4 (0.54) FGFR1FGFR4FGFR2FGFR3KDR
SCHEMBL4398569 0.70 FGFR4 (0.58) FGFR1FGFR4FGFR2FGFR3KDR
SCHEMBL3975638 0.70 FGFR4 (0.75) FGFR1FGFR4FGFR2FGFR3KDR
SCHEMBL4398700 0.69 FGFR4 (0.57) FGFR1FGFR4FGFR2FGFR3KDR
SCHEMBL4403309 0.69 FGFR1 (0.50) FGFR1FGFR4FGFR2FGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1549651-A1 KINASE INHIBITORS Warner-Lambert Company LLC (US) 2005-07-06 — — EP disclosed
WO-2004011465-A1 KINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-05 — — WO disclosed