Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6279684 | 1.00 | HPGD (0.51) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL254627 | 0.91 | HPGD (0.50) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8204647 | 0.84 | MEN1 (0.55) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL31080706 | 0.83 | MEN1 (0.53) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL31080651 | 0.83 | MEN1 (0.53) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL31080739 | 0.83 | MEN1 (0.53) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL31080723 | 0.83 | MEN1 (0.53) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL31080100 | 0.83 | MEN1 (0.53) | HPGDMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL19063624 | 0.83 | NR1H2 (0.47) | HPGDHSD17B10USP30RECQLEPHX1 | |
| SCHEMBL19063623 | 0.83 | NR1H2 (0.47) | HPGDHSD17B10USP30RECQLEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6914140-B1 | Asymmetric synthesis process | HOFFMANN-LA ROCHE INC. (US) | 2005-07-05 | — | — | US | claimed |
| US-6914140-B1 | Asymmetric synthesis process | HOFFMANN-LA ROCHE INC. (US) | 2005-07-05 | — | — | US | disclosed |
| US-6069245-A | PRODUCING A 3-BENZOYLAMINO-4-BENZOYLOXYHEXAHYDROAZEPINE BY THE CATALYTIC HYDROGENATION OF THE 4-OXO-AMINE SALT DERIVATIVE; PROTECTING THE RING NITROGEN; FORMING A FUSED RING; HYDROLYSIS; ACYLATION AND DEPROTECTING | HOFFMANN-LA ROCHE INC. (US) | 2000-05-30 | — | — | US | disclosed |
| US-5902882-A | ASYMMETRICALLY HYDROGENATING AN AZEPINE COMPOUND IN THE PRESENCE OF A RUTHENIUM-DIPHOSPHINE COMPLEX CATALYST | HOFFMANN-LA ROCHE INC. (US) | 1999-05-11 | — | — | US | disclosed |