Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.71 |
| ▸ | CDK4 | P11802 | 1/20 | 0.71 |
| ▸ | CCND1 | P24385 | 1/20 | 0.71 |
| ▸ | CCND3 | P30281 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247993 | 0.85 | KDR (1.00) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL5247997 | 0.85 | KDR (1.00) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL5247427 | 0.84 | KDR (1.00) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL5247433 | 0.84 | KDR (1.00) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL5249781 | 0.84 | KDR (0.82) | KDRCHEK1FGFR1 | |
| SCHEMBL5249045 | 0.83 | KDR (1.00) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL5250160 | 0.83 | KDR (1.00) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL5250165 | 0.83 | KDR (1.00) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL5249432 | 0.83 | KDR (1.00) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL5252259 | 0.81 | KDR (1.00) | KDRCHEK1FGFR1LCKCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1218348-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001002369-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |