Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.55 |
| ▸ | MTOR | P42345 | 13/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629154 | 0.92 | PIK3CA (0.65) | PIK3CAMTOR | |
| SCHEMBL628343 | 0.80 | PIK3CA (0.68) | PIK3CAMTORPIK3R1ATM | |
| SCHEMBL628184 | 0.80 | MTOR (0.68) | PIK3CAMTOR | |
| SCHEMBL629552 | 0.79 | PIK3CA (0.57) | PIK3CAMTORPIK3CD | |
| SCHEMBL628005 | 0.79 | PIK3CA (0.57) | PIK3CAMTORPIK3CD | |
| SCHEMBL628458 | 0.76 | PIK3CA (0.75) | PIK3CAMTOR | |
| SCHEMBL628719 | 0.76 | PIK3CA (0.66) | PIK3CAMTOR | |
| SCHEMBL629722 | 0.76 | PIK3CA (0.66) | PIK3CAMTOR | |
| SCHEMBL628076 | 0.73 | PIK3CA (0.69) | PIK3CAMTOR | |
| SCHEMBL1409805 | 0.71 | PIK3CA (1.00) | PIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419432-A1 | PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010120998-A1 | PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |