Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 16/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412816 | 0.94 | FGFR4 (0.45) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4403819 | 0.93 | FGFR4 (0.44) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4398045 | 0.92 | FGFR1 (0.46) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4401853 | 0.91 | FGFR4 (0.47) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4412769 | 0.90 | FGFR4 (0.46) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL4395942 | 0.89 | FGFR1 (0.48) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL4398107 | 0.87 | FGFR1 (0.49) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4410324 | 0.86 | FGFR1 (0.49) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL4398606 | 0.86 | FGFR4 (0.52) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL4411713 | 0.86 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549651-A1 | KINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011465-A1 | KINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-05 | — | — | WO | disclosed |