Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28279600 | 0.80 | KDM4E (0.53) | KDM4ECYP3A4MAPTALDH1A1ALOX15 | |
| SCHEMBL287699 | 0.79 | KDM4E (0.57) | KDM4ECYP3A4MAPTALDH1A1ALOX15 | |
| SCHEMBL5174868 | 0.74 | KDM4E (0.62) | KDM4ECYP3A4MAPTALDH1A1ALOX15 | |
| SCHEMBL2512862 | 0.74 | KDM4A (0.49) | KDM4ECYP3A4MAPTALDH1A1ALOX15 | |
| SCHEMBL28222564 | 0.74 | CYP2A6 (0.52) | CYP3A4BLMCYP2A6CYP2B6CYP2C9 | |
| SCHEMBL2323790 | 0.73 | KDM4E (0.50) | KDM4ECYP3A4MAPTALDH1A1ALOX15 | |
| SCHEMBL5258713 | 0.73 | KDM4E (0.50) | KDM4ECYP3A4MAPTALDH1A1ALOX15 | |
| SCHEMBL3390642 | 0.73 | KDM4E (0.59) | KDM4ECYP3A4MAPTALDH1A1ALOX15 | |
| SCHEMBL2563987 | 0.73 | KDM4E (0.42) | KDM4ECYP3A4MAPTALDH1A1ALOX15 | |
| SCHEMBL15730156 | 0.73 | CYP2A6 (0.50) | CYP3A4CYP2A6CYP2B6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903097-B2 | Heterocycle carboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY (US) | 2005-06-07 | — | — | US | disclosed |
| US-20040142928-A1 | Heterocycle carboxamides as antiviral agents | BUNDY GORDON L (US) | 2004-07-22 | — | — | US | disclosed |
| US-20030207880-A1 | Heterocycle carboxamides as antiviral agents | BUNDY GORDON L (US) | 2003-11-06 | — | — | US | disclosed |
| US-6559145-B2 | Herpes virus | PHARMACIA & UPJOHN COMPANY | 2003-05-06 | — | — | US | disclosed |
| EP-1301493-A2 | HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2003-04-16 | — | — | EP | disclosed |
| US-20020025960-A1 | Heterocycle carboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-02-28 | — | — | US | disclosed |
| WO-2002004444-A2 | HETEROCYCLE CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-01-17 | — | — | WO | disclosed |
| US-3963733-A | 3-(P-methoxybenzylthio)2-non-oxocarbonylic pyridines | SMITHKLINE CORPORATION (US) | 1976-06-15 | — | — | US | disclosed |
| US-3963733-A | 3-(P-methoxybenzylthio)2-non-oxocarbonylic pyridines | SMITHKLINE CORPORATION (US) | 1976-06-15 | — | — | US | disclosed |
| US-3873552-A | Process and intermediates for preparing 3-thiolpicolnic acid | SMITHKLINE BECKMAN CORPORATION | 1975-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142928-A1 | Heterocycle carboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, HDAC1 | KDM4E 201/4885CYP3A4 851/4885MAPT 4388/4885 |
| US-20020025960-A1 | Heterocycle carboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, HDAC1 | KDM4E 201/4885CYP3A4 851/4885MAPT 4388/4885 |
| US-20030207880-A1 | Heterocycle carboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, HDAC1 | KDM4E 201/4885CYP3A4 851/4885MAPT 4388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.