Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.54 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.54 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.54 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660115 | 0.85 | HPGD (0.62) | HPGDPOLBKMT2ANPC1RAB9A | |
| SCHEMBL9925290 | 0.85 | HPGD (0.62) | HPGDPOLBKMT2ANPC1RAB9A | |
| SCHEMBL6289160 | 0.85 | HPGD (0.62) | HPGDPOLBKMT2ANPC1RAB9A | |
| SCHEMBL28747980 | 0.83 | KDM4E (0.65) | NPC1RAB9ASMN1; SMN2PLAAT3PLAAT5 | |
| SCHEMBL16681873 | 0.82 | NPC1 (0.74) | HPGDPOLBKMT2ANPC1RAB9A | |
| SCHEMBL4584283 | 0.82 | NPC1 (0.64) | HPGDPOLBKMT2ANPC1RAB9A | |
| SCHEMBL17335855 | 0.82 | HPGD (0.73) | HPGDPOLBKMT2ANPC1RAB9A | |
| SCHEMBL661278 | 0.81 | KDM4E (0.72) | HPGDPOLBKMT2ANPC1RAB9A | |
| SCHEMBL18997626 | 0.81 | NPC1 (0.62) | HPGDPOLBKMT2ANPC1RAB9A | |
| SCHEMBL14511344 | 0.81 | HPGD (0.59) | HPGDPOLBKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |