Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 11/20 | 1.00 |
| ▸ | F10 | P00742 | 11/20 | 1.00 |
| ▸ | PRSS1 | P07477 | 11/20 | 1.00 |
| ▸ | PLG | P00747 | 10/20 | 1.00 |
| ▸ | PLAU | P00749 | 10/20 | 1.00 |
| ▸ | PLAT | P00750 | 8/20 | 1.00 |
| ▸ | F7 | P08709 | 9/20 | 0.61 |
| ▸ | F3 | P13726 | 6/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.58 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.58 |
| ▸ | HPN | P05981 | 2/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.53 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6290117 | 0.83 | F2 (1.00) | F2F10PRSS1PLGPLAU | |
| SCHEMBL6289478 | 0.82 | F2 (0.76) | F2F10PRSS1PLGPLAU | |
| SCHEMBL29941378 | 0.81 | F2 (1.00) | F2F10PRSS1PLGPLAU | |
| SCHEMBL6290381 | 0.81 | F2 (1.00) | F2F10PRSS1PLGPLAU | |
| SCHEMBL6292953 | 0.78 | F2 (0.70) | F2F10PRSS1PLGPLAU | |
| SCHEMBL6293507 | 0.77 | F7 (0.76) | F2F10PRSS1PLGPLAU | |
| SCHEMBL7611551 | 0.72 | F7 (0.77) | F2F10PRSS1PLGPLAU | |
| SCHEMBL6289154 | 0.71 | F2 (0.78) | F2F10PRSS1PLGPLAU | |
| SCHEMBL6289508 | 0.71 | HPN (0.63) | F2F10PRSS1PLGPLAU | |
| SCHEMBL6389292 | 0.71 | F7 (1.00) | F2F10PRSS1PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | claimed |
| EP-1140859-A2 | (HETERO)ARYL-BICYCLIC HETEROARYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000035886-A2 | (HETERO)ARYL-BICYCLIC HETEROARYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-06-22 | — | — | WO | claimed |
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1140859-A2 | (HETERO)ARYL-BICYCLIC HETEROARYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035886-A2 | (HETERO)ARYL-BICYCLIC HETEROARYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-06-22 | — | — | WO | disclosed |