Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | TEK | Q02763 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 5/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6295052 | 0.87 | FLT1 (0.66) | FLT1KDRTEKKDM4ECYP3A4 | |
| SCHEMBL4774600 | 0.82 | FLT1 (0.57) | FLT1KDRTEKKDM4ECYP3A4 | |
| SCHEMBL4774594 | 0.82 | FLT1 (0.57) | FLT1KDRTEKKDM4ECYP3A4 | |
| SCHEMBL4774688 | 0.80 | TEK (0.65) | FLT1KDRTEKKDM4ECYP3A4 | |
| SCHEMBL4774694 | 0.80 | TEK (0.65) | FLT1KDRTEKKDM4ECYP3A4 | |
| SCHEMBL8913214 | 0.77 | FLT1 (0.51) | FLT1KDRTEKKDM4ECYP3A4 | |
| SCHEMBL8913217 | 0.77 | FLT1 (0.51) | FLT1KDRTEKKDM4ECYP3A4 | |
| SCHEMBL4103303 | 0.77 | KDM4E (0.55) | FLT1KDRTEKKDM4ECYP3A4 | |
| SCHEMBL4775402 | 0.76 | TEK (1.00) | FLT1KDRTEKKDM4EMAPT | |
| SCHEMBL4775408 | 0.76 | TEK (1.00) | FLT1KDRTEKKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575963-A1 | THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058776-A1 | THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |