Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 11/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291337 | 0.80 | KMT2A (0.47) | KMT2ARIPK3MAPK14MAPK11MAPK13 | |
| SCHEMBL7009927 | 0.80 | KMT2A (0.47) | KMT2ARIPK3MAPK14MAPK11MAPK13 | |
| SCHEMBL6291378 | 0.77 | RIPK3 (0.44) | KMT2ARIPK3MAPK14MAPK11MAPK13 | |
| SCHEMBL6294031 | 0.74 | KMT2A (0.42) | KMT2ARIPK3MAPK14 | |
| SCHEMBL27492751 | 0.71 | KMT2A (0.47) | KMT2ARIPK3MAPK14MAPK11MAPK13 | |
| SCHEMBL6291350 | 0.71 | KMT2A (0.47) | KMT2ARIPK3MAPK14MAPK11MAPK13 | |
| SCHEMBL6290029 | 0.71 | KMT2A (0.47) | KMT2ARIPK3MAPK14MAPK11MAPK13 | |
| SCHEMBL6294484 | 0.70 | KMT2A (0.69) | KMT2ARIPK3MAPK14 | |
| SCHEMBL6291391 | 0.69 | KMT2A (0.51) | KMT2ARIPK3MAPK14 | |
| SCHEMBL6291300 | 0.69 | KMT2A (0.51) | KMT2ARIPK3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867211-B2 | 4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy | MERCKLE GMBH (DE) | 2005-03-15 | — | — | US | disclosed |